Work

Virulence between ESBL and non-ESBL producing isolates of Acinetobacter baumanii causing diabetic foot infections

Year: 2025

Type: article

Abstract: Acinetobacter baumannii is an opportunistic pathogen associated commonly with healthcare-associated-infections and predominantly involved in diabetic foot infections with virulence factors determining pathogenicity especially in multidrug resistant strains. Therefore, it is of interest to compare virulence factors (pellicle formation and gelatinase activity) between Extended-spectrum beta-lactamase (ESBL) and non-ESBL producing Acinetobacter baumannii isolates derived from diabetic foot ulcer infection (DFI). The isolates were identified using standard microbiological methods and antimicrobial susceptibility test was done by Kirby Bauer disk diffusion method. The double disk synergy test method (DDST) was used to detect ESBL production. The formation of pellicle at 37°C and gelatinase production indicated high virulence in ESBL producers. Colistin and polymyxin B were found to be the only options effective against multidrug-resistant Acinetobacter baumannii infections.

Source: Bioinformation

DOI: 10.6026/973206300212942

Authors: Hirdesh Kumari Gupta, Ramanath Karicheri, Abhishek Mehta

Institution: Index Medical College, Hospital & Research Centre

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414329198