Year: 2025
Type: article
Abstract: Nanobodies (Nbs) are antigen-binding fragments derived from unique heavy-chain-only antibodies. In recent years, the development of Nbs has progressed rapidly due to their therapeutic potential. Here we present a comprehensive patent landscape of Nb technologies, focusing on uncovering innovation trends, identifying novel drug candidates, and analyzing opportunities and challenges for research, development, and commercialization. Using B-cell maturation antigen (BCMA) as an example drug target, we summarize the features, physicochemical properties, modification sites, and epitope-binding tendencies of patented sequences of Nb drugs, highlighting the importance of structural-level patent protection, and offering a theoretical foundation for Nb design and experimental validation. Through patent landscape and patent sequence analysis, our study provides valuable insights for Nb drug development and supports decision-making in patent strategy.
Source: mAbs
Authors: Jiaqi Xu, Yan Wang, Ni Yuan, Guang Hu, Yuanjia Hu
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,575
Funder: Universidade de Macau
OpenAlex ID: W4414337519