Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC
Year: 2025
Type: article
Abstract: Hsa_circ_0058495 promotes PDAC progression by stabilizing IGF2BP2 and activating the MEKK1-ERK signaling cascade, while exosomal transfer of hsa_circ_0058495 drives M2 macrophage polarization to reinforce tumor-associated immunosuppression. These findings establish hsa_circ_0058495 as a pivotal regulator of PDAC progression and underscore its potential utility as both a diagnostic biomarker and a therapeutic target.
Source: Theranostics
DOI: 10.7150/thno.117202
Authors: Shengnan Lv, Jian Zhang, Xinyu Peng, Huan Liu, Tongjia Chu, Ziyu Liu, Kehang Duan, Jianxiong Guo, Jie Wang, Yan Liu, Feng Wei
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4414345810