Work

Design, modular synthesis and screening of 58 shape-diverse 3-D fragments

Year: 2025

Type: article

Abstract: -glycosylation pathway and a promoter of aggressive metastatic cancers, underscoring the breadth of biological space that can be explored.

Source: Chemical Science

DOI: 10.1039/d5sc05819h

Authors: Thomas D. Downes, S. Paul Jones, James D. Firth, John F. Darby, Amelia K. Gilio, Hanna F. Klein, Xinyu Wang, David C. Blakemore, Claudia De Fusco, Stephen D. Roughley, Lewis R. Vidler, Maria Ann Whatton, Alison J.-A. Woolford, Gail L. Wrigley, Roderick E. Hubbard, Liang Wu, Gideon J. Davies, Peter O'Brien

Institutions: University of York, Pfizer (United States), AstraZeneca (United Kingdom), Vernalis (R&D) Limited (United Kingdom), Eli Lilly (United Kingdom), Astex Pharmaceuticals

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Eli Lilly and Company, Pfizer, AstraZeneca, University of York, Wellcome Trust, Diamond Light Source, Astex Pharmaceuticals, Royal Society, China Scholarship Council, Biotechnology and Biological Sciences Research Council, Horizon 2020

Awards: G3100032627, G4912766490, G540949950, G6113678532, G6582298172, Investigating the molecular basis of Heparan Sulfate biosynthesis, Fragment-based activation and modification of industrial enzymes, Investigating the molecular basis of Heparan Sulfate biosynthesis

OpenAlex ID: W4414351672

FWCI: 1.008

Cites: 54

Cited by: 4

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