Year: 2025
Type: article
Study design: Observational Study
Abstract: Background. Atopic dermatitis (AD) chronic inflammatory skin disease developing associated with genetically determined skin barrier disorders and immune system impairment. In recent years, there is an increase in the proportion of patients with autoimmune diseases (AIDs) among AD cases. Objective. The aim of the study is to examine AIDs incidence among children hospitalized with AD. Methods. The study included patients with moderate or severe AD hospitalized in specialized hospital department from November 2015 to April 2025. AIDs and allergic diseases presence was determined according to medical records. Results. The study included 10,239 patients with AD. Comorbidities (1) were diagnosed in 8103 (79.1%) children, allergic diseases — in 6475 (63.2%). At least one AID was diagnosed in 1,628 children (15.9%; 95% CI 15.3–16.7%). The most common were alopecia areata, celiac disease, and vitiligo. Conclusion. Examination of patients with moderate or severe AD should include evaluation of AIDs symptoms and immunological markers. Common pathogenetic mechanisms allow us to develop united strategy for AD and AIDs early diagnosis and for further follow-up of patients at high-risk group.
Source: Вопросы современной педиатрии
Author: Ekaterina S. Pavlova
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414352105