Work

Curcumin Promotes Mitochondrial Apoptosis of Cancer-derived Lung Cancer Stem Cells and Cisplatin Sensitization Through BH3-only Dephosphorylation

Year: 2025

Type: article

Abstract: Background Lung cancer’s mortality ranks first among other cancers. Several studies have shown the role of microRNAs in the pathogenesis of lung cancer. Objectives This study investigates microRNA-1297’s (miR-1297) role in lung cancer. Materials and Methods Cisplatin (DDP)-resistant cells A549/DDP and NCI-H460/DDP were utilized to measure cell proliferation and BH3-only expression. Results miR-1297 was upregulated in A549/DDP and NCI-H460/DDP cells, and BH3-only was downregulated. DDP inhibited the proliferation of A549/DDP and NCI-H460/DDP cells. BH3-only is the target gene of miR-1297. BH3-only was upregulated by the miR-1297 inhibitor, resulting in increased cell apoptosis, impaired proliferation, and drug resistance. Conclusion DDP resistance in lung cancer is associated with the miR-1297 level. Its downregulation induces DDP drug resistance by upregulating BH3-only.

Source: Pharmacognosy Magazine

DOI: 10.1177/09731296251367935

Authors: Zhigang Lu, Chunlin Li, Jiayang Sun

Institution: Inner Mongolia Medical University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,600