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Association of Coenzyme Q10 Supplementation With Statin-Associated Muscle Symptoms in Long-Term Statin Users

Year: 2025

Type: article

Abstract: INTRODUCTION: Statins are among the most commonly prescribed medications for lowering blood cholesterol levels and are considered safe and effective. However, statin-associated muscle symptoms (SAMS) remain a frequent adverse effect encountered in clinical settings. OBJECTIVE: To compare the effectiveness of coenzyme Q10 (CoQ10) with no supplementation in the management of statin-associated muscle symptoms among patients on statin therapy. METHODS: This observational study was conducted in the Department of Medicine at the Pakistan Institute of Medical Sciences (PIMS), Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, over a period of six months following ethical approval. A total of 106 patients with clinically identified SAMS were included. Group A (n=53) comprised patients who received CoQ10 (50 mg twice daily), while Group B (n=53) included patients who received no supplementation and were managed conservatively. Results: Patients in Group A who received CoQ10 showed a greater reduction in both VAS and pain interference scores compared to Group B. The differences between the two groups were statistically significant (p = 0.001), suggesting better symptom control in the CoQ10 group. CONCLUSION: CoQ10 supplementation (50 mg twice daily) was associated with improved control of statin-associated muscle symptoms in an observational clinical setting. These findings support its potential role as an adjunctive option for patients experiencing muscle-related side effects from statin therapy.

Source: Cureus

DOI: 10.7759/cureus.92705