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In vitro anticoagulant and thrombolytic activities of the stem bark of Ficus mucuso Welw. ex Ficalho (Moraceae)

Year: 2025

Type: article

Abstract: Cerebral Vascular Accidents represent a diagnostic and therapeutic emergency that is difficult to access for populations in sub-Saharan countries. Hence, the present study aimed to evaluate the anticoagulant and thrombolytic properties of the stem bark of Ficus mucuso, a plant whose decoct is used in the treatment of post-stroke sequelae in Ivory Coast. In vitro anticoagulant and thrombolytic tests were carried out using fresh blood from albino laboratory rats, Wistar strain. The results and statistical analysis showed that the aqueous (EAq) and ethanolic (EEt) extracts of the stem bark of the plant present, at 0.1 mg/mL, an anticoagulant activity and a thrombolytic potential similar to that of enoxaparin sodium at 200 IU/mL (p > 0.05). In numerical value, EAq presented a lysis percentage of 17.70%, 16.83% for EEt and 16.55% for enoxaparin sodium. The stem bark of F. mucuso therefore has excellent anticoagulant and thrombolytic potential and could serve as a biological support for the implementation of an Improved Traditional Medicine useful in the urgent treatment of victims of Cerebral Vascular Accidents.

Source: International Journal of Biological and Chemical Sciences

DOI: 10.4314/ijbcs.v19i3.2

Authors: Serge Cherry Piba, Yéli Gninekan Ramata Coulibaly, Djè KouaméWenceslas Kouame, Amoin Gervaise Kouame, Idrissa Doumbia, Bi Fezan Honora Tra

Language: English

Topic: Phytochemistry and biological activities of Ficus species

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414354288

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