Three-Decade Analysis of Inflammatory Bowel Disease in Türkiye: A Multicenter Study (1993-2024)
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background/Aims: Inflammatory bowel diseases (IBDs) are increasingly prevalent and challenging globally. Data regarding IBD frequency and severity between Europe and Asia are needed. The aim was to investigate the trend of IBD in Türkiye during the last 3 decades. Materials and Methods: The study was conducted retrospectively at 14 centers in Türkiye between June 1993 and March 2024. Results: Over 30 years, 4308 patients, of whom 2507 (58.2%) had ulcerative colitis (UC) and 1717 (39.9%) had Crohn's Disease (CD), were included in the study. The overall median age at the onset of IBD was 34.43 (25.28-45.64) years; the age at onset of IBD was younger in CD compared to UC (32.72 vs. 35.52 years respectively, P < .001). The peak age onset range was 28-32 years in CD, whereas 23-27 years in UC. Overall, 2526 (58.6%) patients were male. The most common location was left-sided colitis in UC patients (45.1%), followed by extensive colitis (31.2%), and proctitis (23.7%), while ileal involvement in CD patients (45.2%), afterward ileocolonic (409%), and colonic (13.5%). Both illnesses are becoming increasingly prevalent. The UC/CD ratio tends to decrease over time. During the study period, 1577 (36.6%) patients received biologic treatment. During the study period, 418 (24.3%) underwent resective surgery for CD and 88 (3.5%) total colectomy for UC; the major abdominal surgery has declined over time. Conclusion: The frequency and characteristic features of IBD in Türkiye appear to be between Europe and Asia. Over time, while the usage of biologic therapy and the rate of CD have increased, the frequency of surgery has decreased.
Authors: Muhammed Bahaddin Durak, Yasir Furkan Cagin, Ayhan Balkan, Yusuf Coskun, Tarkan Karakan, Yavuz Cagir, Yavuz Beyazit, Ali Atay, Ali Can Erdem, Guray Can, Engin Altinkaya, Hakan Dursun, Orhan Coskun, Mehmet Rasit Ayte, Mevlut Hamamci, Ilyas Tenlik, Cem Simsek, Abdurrahman Sahin, Huseyin Koseoglu, Mustafa Akar, Kenan Kosar, Bulent Albayrak, Eylem Karatay, Murat Kekilli, Mehmet Asil, Hilmi Ataseven, Mehmet Cindoruk, Ilhami Yuksel
Institutions: Hacettepe University, Malatya Turgut Özal Üniversitesi, Turgut Özal University, Gaziantep University, Ankara Etlik City Hospital, Gazi University, Ankara Yıldırım Beyazıt University, Çanakkale Onsekiz Mart Üniversitesi, Ankara Bilkent City Hospital, Necmettin Erbakan University, Sivas Cumhuriyet Üniversitesi, Atatürk University, Ankara Atatürk Eğitim ve Araştırma Hastanesi, Tokat Gaziosmanpaşa Üniversitesi, Hitit Üniversitesi, Sağlık Bilimleri Üniversitesi, S.B.Ü. Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Karabük University, Istinye University
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414355098
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