Work

Two new lignanamides from the fruits of Tribulus terrestris with NO production inhibitory activity

Year: 2025

Type: article

Abstract: Lignanamides are lignans containing amide functional groups, which show significantly anti‐inflammatory. From the Tribulus terrestris fruits, six lignanamides ( 1 ‐ 6 ) and four other nitrogen compounds ( 7 ‐ 10 ) were isolated. Of which, compounds 1 and 2 were previously undescribed. Their structures were elucidated by HR‐ESI‐MS, 1D, 2D‐NMR, and ECD spectra in comparison with the reported data. Lignanamides 1 – 6 significantly exhibited NO production inhibitory activity in LPS activated RAW 264.7 cells with IC 50 values ranging from 5.8 to 26.5 µM.

Source: Vietnam Journal of Chemistry

DOI: 10.1002/vjch.70061

Authors: Nguyen Van Quoc, Bui Huu Tai, Nguyen Huy Hoang, Dan Thi Thuy Hang, Pham Hai Yen, Phan Van Kiem

Institutions: Vinh University, Viện Hóa học, Vietnam Academy of Science and Technology

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400