Investigation on the Anti-Cancer Effects of HER2-Targeted CAR-T Cells Engineered Using the PiggyBac Transposon System
Year: 2025
Type: article
Abstract: Background: Chimeric antigen receptor T (CAR-T) cell therapies have demonstrated significant clinical efficacy in hematological malignancies. However, their application to solid tumors remains substantially limited by multiple challenges, including the risk of off-target effects. Hence, optimizing CAR-T cells for stronger antigen binding is essential. Methods: transposon-mediated gene transfer were compared. Results: breast tumor xenograft model, with anti-HER2-13 CAR-T cells demonstrating slightly enhanced efficacy and no evident off-target toxicity. Conclusion: These results highlight the potential of anti-HER2-13 CAR-T cells to serve as a safer and more efficacious alternative in HER2-targeted therapy.
Authors: Tian-Tian Li, Ming-Yao Meng, Zheng Yu, Yang-Fan Guo, Yi-Yi Zhao, Hui Gao, Li-Li Yang, Li-Rong Yang, Meng-Yuan Chu, Shan He, Yuan Liu, Xiao-Dan Wang, Wen-Ju Wang, Zong-Liu Hou, Li-Wei Liao, Lin Li
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414358550