Synthesis and biological evaluation of some new tetrazole derivatives by using oxazine and thiazine compounds
Year: 2025
Type: article
Abstract: This research included, in its first part, the preparation of the chalcone compound (M) from the reaction of para-nitroacetophenone with benzaldehyde in a basic medium of 40% aqueous sodium hydroxide solution. The second part of the research included the conversion of the compound (M) into the two compounds derived from 2-amino Thiazine (MS) and 2-aminooxazine (MO) by reacting the compound (M) with thiourea or urea, respectively, in a medium of alcoholic sodium hydroxide. In the third part of the research, the amine group in the two compounds (MS) and (MO) was exploited to prepare Schiff bases (MS1-4) and (MO1-4) through the reaction of the two compounds (MS) and ((MO) with some benzaldehyde derivatives. In the last part of the research, the tetrazole compounds (MST1-4) and (MOT1-4) were prepared From the reaction of the prepared Schiff bases (MS1-4) and (MO1-4) with sodium azide in a medium of 1,4-dioxane, a test was conducted for the biological effectiveness of the prepared tetrazole compounds against Gram-positive and Gram-negative bacteria. In addition, some spectroscopic and physical measurements were performed of the prepared compounds.
Source: Applied Chemical Engineering
Authors: Mohaymin. A. Abdul karim, Salim J. mohammad, Mohanad. Y. Saleh, Shakir M. Saied
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4414362280
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