Comparison of Opioid-Based and Multimodal Analgesic Regimens for Postoperative Pain Management in Gynecological Surgery
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: INTRODUCTION: Effective postoperative pain management is crucial for patient recovery. Traditional opioids cause significant side effects, including dependency risk. Multimodal analgesia targets multiple pain pathways, reducing opioid consumption while improving outcomes. METHODS: This is a prospective study that was conducted over six months at Muhammad Teaching Hospital, Peshawar, with 100 participants undergoing elective gynecological surgery. Participants were randomly assigned to receive either multimodal analgesia or traditional analgesia. Data were collected on VAS (Visual Analogue Scale) pain scores, opioid consumption, adverse effects, and patient satisfaction levels. RESULTS: Patients in the multimodal group demonstrated significantly lower VAS pain scores at all time points (one hour: 4.1 ± 0.77 vs. 6.4 ± 0.63, p < 0.01; 24 hours: 2.76 ± 0.55 vs. 4.66 ± 0.47, p < 0.01), reduced opioid consumption (6.4 mg vs. 13 mg in the first 24 hours, p < 0.01), and fewer adverse effects including nausea (10% vs. 26%, p < 0.01) and vomiting (8% vs. 26%, p < 0.01) compared to the traditional group. CONCLUSION: Multimodal analgesia is an effective method of pain management that should be offered to postoperative gynecological patients.
Source: Cureus
DOI: 10.7759/cureus.92682
Authors: Ammarah Ahmed, Afnan Amjad
Institution: Lady Reading Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414362329