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Thymoquinone alleviates the adverse effects of cyclophosphamide on oogenesis and in vitro fertilization (IVF) in NMRI mice.

Year: 2025
Type: article
Abstract: Objective: Patients undergoing treatment with antineoplastic drugs face numerous challenges. This study investigates the effects of thymoquinone (Tq) in NMRI mice treated with cyclophosphamide (Cph), aiming to enhance patients' optimism for the future by redirecting their focus towards achieving a normal life and restoring fertility after treatment. Materials and Methods: Female NMRI mice were divided into five groups: Control, Sham, Cph-treated (CPH), and two groups treated with Tq alongside Cph (TQ5 and TQ10). All mice were sacrificed to aspirate their oocytes for further analysis. The development of embryos up to the blastocyst stage was assessed using in vitro fertilization (IVF) with mature oocytes. Results: compared to the CPH group. Conclusion: ) and oxidative damage in ovarian tissues following CPH-induced oocyte degeneration in mice.
Source: PubMed
DOI: 10.22038/ajp.2025.25734
Authors: Sima Etebari, Vajihe Rouki, Mohsen Asouri, Mehrab Nasirikenari, Seyed Elyas Meshkani, Mohammad Reza Momtaz, Sakineh Amoueian, Yahya Babaki, Fateme Hajati, Ali Asghar Ahmadi
Institutions: Sabzevar University of Medical Sciences, Ferdowsi University of Mashhad, Mazandaran University of Medical Sciences, Pasteur Institute of Iran, Emam Reza Hospital, Imam Reza Hospital, Shahid Beheshti University of Medical Sciences
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W4414371624
FWCI:
Cites: 1
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