Work

Discovery of Novel 4,5-Dihydropyrrolo[3,4- c ]pyrazol-6( 2H )-one-Based Tubulin Inhibitors Targeting Colchicine Binding Site with Potent Anti-Ovarian Cancer Activity

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00014

Authors: Quanwei Yu, Yujie Liu, Zhijia Wang, Chengyong Wu, Ruofei Zhang, Lun Tan, Lele Zhang, Cuiyu Guo, Lantu Gou, Weimin Li, Yang He, Yuxi Wang

Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: National Natural Science Foundation of China

Award: G5563064227

OpenAlex ID: W4414372267

FWCI: 1.192

Cites: 37

Cited by: 4

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