Year: 2025
Type: article
Abstract: The purpose of this study was to use silica-based formulations to improve the solubility and rate of dissolution of phenylbutazone, a medication that is poorly soluble in water. Using a solvent-free process that involved hydration, heating, and drying, Syloid silica (AL-1FP) was used to create solid dispersions at drug-to-excipient ratios of 1:1, 2:1, and 1:3. The formulations were characterized using dissolution testing, Fourier Transform Infrared Spectroscopy, X-ray diffraction, Differential Scanning Calorimetry, and Scanning Electron Microscope. The results confirmed the drug’s transition from crystalline to amorphous states, and pore entrapment in the silica matrix markedly improved dissolution. The most significant promotion was experienced with the 1:3 ratios, which released 98.9% of phenylbutazone after 45 minutes compared to 31.9% for the pure medication. This illustrates the effectiveness of Syloid silica in overcoming the solubility limitations of BCS class II drugs, providing a scalable approach for veterinary formulations
Source: ChemClass Journal
Institutions: Sokoto State University, Usmanu Danfodiyo University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4414374556
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