Comparative Evaluation of the Effect of Different Matrix Metalloproteinase Inhibitors on Shear Bond Strength between Composite and Dentin: An In Vitro Study
Year: 2025
Type: article
Abstract: on synthetic MMP inhibitors, such as chlorhexidine (CHX), ethylenediaminetetraacetic acid (EDTA), and tetracycline derivatives, which have shown promise in preventing MMPmediated collagen degradation.7 Chlorhexidine, for instance, has been widely studied for its ability to inhibit MMP-2, -9, and -8 on dentin surfaces.By effectively reducing MMP activity, CHX helps maintain the structural integrity of the hybrid layer, thereby enhancing the long-term bond strength between resin and dentin.8 Similarly, EDTA acts by chelating metal ions essential for MMP activation, thereby hindering their IntroductIonDental adhesive materials have significantly advanced, improving in composition, application, and efficacy.1 Their effectiveness depends on achieving a stable bond between composite resin and tooth structure through dentin demineralization and hybrid layer formation.2 However, incomplete resin penetration can leave collagen fibrils vulnerable to degradation by matrix metalloproteinases (MMPs).3 Matrix metalloproteinases are enzymes that play a pivotal role in degrading components of the extracellular matrix, including collagen within dentin.These enzymes, activated in acidic environments created by caries or during dental procedures, can lead to the breakdown of the hybrid layer over time.4 This degradation weakens the adhesive interface between the resin and dentin, potentially resulting in clinical issues like recurrent cavities, tooth sensitivity, or even premature restoration failure.5 Thus, preserving the integrity of the hybrid layer and enhancing the durability of resin-dentin bonds are critical goals in contemporary adhesive dentistry.3 To address these challenges, various strategies have been explored to inhibit MMP activity and thereby improve bond longevity.One approach involves the use of tissue inhibitors of metalloproteinases (TIMPs), which naturally regulate MMP function in tissues.6 Another approach focuses
Authors: Nupur Ninawe, Nilam V Honaje, Anija CK, Snehal D Jagtap
Institution: Govt. Dental College & Hospital
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414376437