Work

Stochastic HIV-1 infection model with time delay: case study of clinical data

Year: 2025

Type: article

Abstract: is constructed, and the sufficient conditions for virus extinction and weak persistence are given. Subsequently, we respectively fit the SDDE and ODE models to the real data, and conduct a sensitivity analysis of the equilibrium. The greater the noise intensity, the more obvious the oscillation amplitude of the solution curve around the immune-free equilibrium, the larger noise intensity can cause the originally persistent virus in ODE to go extinct in the SDDE model. The greater the time delay, the longer it takes for the virus and immune cells to reach their first peaks. The viral replication rate significantly affects the virus-immune system, and the reproduction of HIV-1 can be inhibited by modulating it. A relatively high viral inhibition rate will lead to the extinction of immune cells while the virus persists.

Source: Journal of Biological Dynamics

DOI: 10.1080/17513758.2025.2553766

Authors: Yan Li, Yongchang Wei, Shuang Li, Yong Li, Zhihang Peng

Institutions: Yangtze University, Henan Normal University, Chinese Center For Disease Control and Prevention, Nanjing Medical University

Language: English

Topic: Mathematical and Theoretical Epidemiology and Ecology Models

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,533