Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries. OBJECTIVES: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group. MATERIALS AND METHODS: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children. RESULTS: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions. CONCLUSION: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.
Source: Contact Dermatitis
DOI: 10.1111/cod.70033
Authors: Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella‐Fontanillas, Marie L. A. Schuttelaar, Heinrich Dickel, Jonathan White, Györgyi Pónyai, S. Mark Wilkinson, Esen Özkaya, Ella Dendooven, Nives Pustišek, Jeanne Duus Johansen, Olivier Aerts, the European Baseline Series (EBS) Working Party of the European Society of Contact Dermatitis (ESCD)
Institutions: University of Copenhagen, Gentofte Hospital, Amsterdam University Medical Centers, University Hospital Centre Zagreb, University of Zagreb, Jagiellonian University, University of Padua, Unidade Local de Saúde de Coimbra, University of Coimbra, Universitat Pompeu Fabra, Hospital del Mar Research Institute, University of Groningen, St. Josef-Hospital, Ruhr University Bochum, Université Libre de Bruxelles, Semmelweis University, Leeds Teaching Hospitals NHS Trust, Istanbul University, University of Antwerp, Antwerp University Hospital, Children's Hospital Zagreb
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,060
OpenAlex ID: W4414377937