Work

Sustainable optimization of pharmaceutical synthesis: applications and benefits of continuous flow chemistry

Year: 2025

Type: article

Abstract: Continuous flow chemistry is emerging as a transformative strategy for pharmaceutical synthesis, providing a sustainable and efficient alternative to conventional batch processes. Flow systems offer precise control over key reaction variables temperature, pressure, and residence time enhancing product consistency, accelerating reaction rates, and reducing waste in line with Green Chemistry principles. Recent applications include the synthesis of active pharmaceutical ingredients (APIs) such as flibanserin, celecoxib, valsartan, mesalazine, and other complex heterocycles, achieving higher yields, selectivity, and scalability. Multicomponent reactions in flow further enable the rapid construction of drug like molecules while minimizing step count and environmental impact. Although challenges remain in equipment cost and scale up, continuous flow technology represents a pivotal step toward safer, faster, and more sustainable pharmaceutical manufacturing.

Source: Green Chemistry Letters and Reviews

DOI: 10.1080/17518253.2025.2549732

Authors: Kelvin Adrian Sanoja-Lopez, Eliana Nope, Rafael Luque

Institution: Universidad Ecotec

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $1,533