Work

Palladium-Catalyzed Asymmetric Carbonylation of Alkynes to Axially Chiral Carbothioate Esters

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Herein, we report a novel palladium-catalyzed asymmetric hydrothioesterification of alkynes under mild conditions, enabling the precise construction of axially chiral carboxylic thioester derivatives with excellent yields, regioselectivity, E / Z selectivity, and enantioselectivity. Disulfides and thiosulfonates were applicable, as well.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c11864

Authors: Wang Yao, Yang Yuan, Ting Yang, Yong-Gui Zhou, Xiao-Feng Wu

Institutions: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian National Laboratory for Clean Energy, Leibniz Institute for Catalysis

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Dalian Institute of Chemical Physics, National Key Research and Development Program of China