New Potential Biomarkers for the Differential Diagnosis of Pericarditis and Myopericarditis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Myopericarditis is an inflammatory disease characterized by elevated cardiac biomarkers. In the absence of elevated cardiac biomarkers, myocardial involvement is subclinical or unclear in most cases of pericarditis. In order to differentiate between pericarditis and myopericarditis, this study sought to fully ascertain the prognostic significance of inflammatory ratios and indicators. Methods: After applying the exclusion criteria, this study comprised 193 patients out of 1220 patients enrolled in our hospital's database in 2022 who satisfied the diagnostic criteria for pericarditis and myopericarditis. Inflammatory scores were calculated from peripheral complete blood counts and analyzed with demographic and clinical data. p < 0.05 was the cutoff point for statistical significance. Results: A total of 193 patients (105 with pericarditis, 88 with myopericarditis) were included. The pericarditis group had more female patients, while myopericarditis was predominantly male (p=0.014). The mean age was 38.39 ± 15.84 years. Inflammatory scores were significantly higher in myopericarditis. In univariate and multivariate logistic regression, NLR, dNLR, and SIRI showed high specificity, sensitivity, and predictability for myopericarditis. ROC and AUC analyses identified NLR, dNLR, and SIRI with the highest AUC values (0.88, 0.85, and 0.85). With a cut-off of 2.45 (p
Source: Akdeniz Medical Journal
DOI: 10.53394/akd.1644187
Authors: Mehmet Özyaşar, Tolga Memioğlu
Institutions: Konya City Hospital, Bolu Abant İzzet Baysal University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414390597