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Safety and quick, long-lasting immune response of the ileitis vaccine in pigs with two schemes at 3 and 5 week-old

Year: 2025
Type: article
Abstract: Ileitis, or proliferative enteritis, is an important problem for industrial pig farming worldwide and in Vietnam. This study aimed to evaluate the safety and antibody response of the Porcilis®Ileitis inactivated vaccine using two vaccination schedules at 3 and 5 weeks of age in an industrial pig farm. The results showed that the vaccine was highly safe after vaccination at 3 and 5 weeks of age regarding both local and systemic reactions. The incidence of mild systemic reactions was less than 1% in the experimental groups V-3-A and V-3-B within two hours after injection. In vaccinated groups, antibody levels quickly reached positive (PI > 30%) two weeks after vaccination. Although the vaccination scheme was delayed at 5 weeks of age (V-5-A and V-5-B), the antibody titer after vaccination increased rapidly, reaching positive after only >1 week and increased higher than the group of pigs vaccinated at 3 weeks of age (groups V-3-A and V-3-B) at 11 weeks of age (6 weeks after vaccination). The antibody titer response after vaccination in experimental pigs remained high (PI = 70 - 80%) until slaughter. The antibody response did not peak during the observation period after vaccination. These findings indicate that the Porcilis®Ileitis inactivated vaccine provides high safety and a rapid, strong, and prolonged antibody response at both 3 and 5 weeks of age; particularly, achieving high titers during the post weaning window in which pigs are particularly susceptible to Lawsonia intracellularis.
DOI: 10.52997/jad.6.04.2025
Authors: Thanh P. Nguyen, Thang D. Hoang, Duyen T. M. Pham, Tram T. N. Ngo, MSD Animal Health Vietnam, Ho Chi Minh City, Vietnam, Nghia D. Tran, Tuyen T. B. Nguyen, Duy T. Do
Language: English
Subfield: Small Animals
Field: Veterinary
Open Access status: diamond
OpenAlex ID: W4414391026
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