Three-Dimensional Numerical Simulation of 90 Sr/ 90 Y Separation by Countercurrent Electrophoresis to Produce Medical 90 Y
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide 90 Y is used to label antibodies and treat the tumors. In a 90 Sr/ 90 Y generator, the decay of 90 Sr produces 90 Y. This study presented the development of a countercurrent electrophoretic separation device as a 90 Sr/ 90 Y generator for producing medical 90 Y. First, the complex stability constant was used to analyze the behavior of ethylenediaminetetraacetic acid (EDTA), citric acid (CIT), and 90 Sr/ 90 Y in different pH environments. Then, the concentration distribution in 90 Sr/ 90 Y separation via countercurrent electrophoresis was systematically investigated using COMSOL simulations, with specific focus on the effects of the temperature, applied voltage, and initial strontium concentration. Finally, the experimental validation further confirmed the technical feasibility of this separation method. As a result, the best simulation results indicated that the separation factor was 9.0 × 10 8 at a temperature of 20 °C, a voltage of 1000 V, and a flow rate of 0.0001 m/s. After consideration of electro-osmotic flow, the separation factor is 9.8 × 10 5, while the best experimental results showed that the separation factor was 8.7 × 10 5 at 20 °C, 1000 V, and 0.0001 m/s.
Source: ACS Omega
Authors: Ziteng Gao, Hu Zhang, Ting Yu, Lu Qiao, Cunxiong Liu
Institution: China Institute of Atomic Energy
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
Award: G4167912925
OpenAlex ID: W4414393308