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Genetic markers of predisposition to athletic performance in Kazakhstani combat athletes: Results of a GWAS study

Year: 2025

Type: article

Abstract: This study investigated genetic markers associated with athletic performance in Kazakhstani combat sport athletes and assessed their potential role in developing a genetic passport for personalized training. A total of 235 elite wrestlers and boxers and 172 controls were enrolled. DNA was extracted from blood and genotyped using the Illumina iScan platform (654,027 SNPs). Genome-wide association analysis was performed in PLINK, and significant variants were annotated using genomic databases. No genome-wide significant associations (p < 5 × 10⁻⁸) were observed, but several SNPs reached suggestive significance (p < 5 × 10⁻⁶). Variants in CDH13, LIMD1, and ZNF215 were most notable. The CDH13 rs79764367 G allele was enriched in wrestlers, while the A allele was associated with boxing. LIMD1 rs77194734 showed allele-specific differences between wrestling and boxing. ZNF215 rs76704889 was linked to elite-level traits in both groups. This pilot GWAS provides the first evidence of candidate genetic markers in Kazakhstani combat athletes, highlighting allele-specific differences across sports disciplines.

Source: International Journal of Innovative Research and Scientific Studies

DOI: 10.53894/ijirss.v8i6.10073

Authors: Madina B. Baurzhan, Aibol T. Kulbayev, Alina V. Ten, Leyla B. Djansugurova, Nazym K. Altynova

Institution: Al-Farabi Kazakh National University

Language: English

Topic: Genetics and Physical Performance

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414395507

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