Work

Perioperative management of severe factor VII deficiency: a single-center experience in China

Year: 2025

Type: article

Abstract: Introduction: Inherited factor VII (FVII) deficiency is a rare autosomal recessive disorder whose clinical phenotypes are highly variable. Many studies have observed the absence of a clear-cut and consistent correlation between bleeding symptoms and FVII levels. Perioperative bleeding is a major concern in patients with FVII deficiency, but validated recommendations about the perioperative management of replacement therapy (RT) with FVII are lacking. Methods: Our study retrospectively summarized and analyzed the perioperative hemostasis management of severe FVII deficiency in 20 patients. Results: We found that replacement therapy is generally effective and that there is no significant correlation between the perioperative hemorrhagic complications after RT and the severity of FVII level before RT. Through multivariate statistical analysis and a retrospective analysis of other coagulation factor deficiencies at our center, we found that postoperative secondary hyperfibrinolysis in patients with FVII deficiency may not be universal. Discussion: Antifibrinolytic treatment may be necessary for patients undergoing surgery at sites with high fibrinolytic activity during the perioperative period. In addition, clinical data such as bleeding phenotype, bleeding history, and surgical sites should be given appropriate attention in perioperative treatment and monitoring.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1673206

Authors: Chao Zhu, Jinxia Zhao, Longqiang Xu, Wenfei Lu, Shiguo Liu, Jialiang Guan

Institutions: Affiliated Hospital of Qingdao University, Qingdao University

Language: English

Topic: Hemophilia Treatment and Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801