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A case report of extranodal NK/T cell lymphoma nasal-type with direct pulmonary involvement

Year: 2025

Type: article

Abstract: RATIONALE: Extranodal nasal-type NK/T-cell lymphoma primarily invades the nasal and nasopharyngeal regions, while direct pulmonary involvement is extremely rare and prone to clinical misdiagnosis or oversight. PATIENT CONCERNS: A 45-year-old man presented with recurrent high fever and cough. Anti-infective therapy and the peaspartase + methotrexate + etoposide + dexamethasone regimen proved ineffective, with chest CT demonstrating disease progression. DIAGNOSES: A patient with extranodal nasal-type NK/T-cell lymphoma, classified as stage IV group B refractory category, predominantly presenting with lung infiltration and concurrent multiorgan involvement of the bone marrow and adrenal glands is described herein. INTERVENTIONS: The disease was controlled only after timely adjustment to a gemcitabine combined with oxaliplatin + PD-1 inhibitor chemotherapy regimen. OUTCOMES: The patient now remains clinically stable with adequate oral intake and satisfactory sleep quality. LESSONS: Clinicians should broaden diagnostic considerations and pay greater attention to heterogeneous tumors. For patients presenting with persistent recurrent fever, pulmonary consolidation lesions, and poor response to anti-infective therapy, prompt percutaneous lung biopsy should be performed to obtain pathological confirmation.

Source: Medicine

DOI: 10.1097/md.0000000000044411

Authors: Hui Zhang, Jiaming Yin, Haibo Ge

Institution: Nanjing University of Chinese Medicine

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950