Objective test findings in patients with chronic eye symptoms seeking care at an outpatient neck center: ligamentous cervical instability etiology?
Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose To examine the incidence and potential associations between eye symptoms and objective test findings in patients reporting to an outpatient neck center without known preexisting conditions. Methods Consecutive patients between January 1 and June 30, 2022, reporting at least 1 of 6 eye symptoms (light sensitivity, blurry vision, eye pain/pressure, vision changes, seeing flashes of light, eye tearing) without known etiology underwent these tests: pupillometry, tonometry, ultrasound of carotid sheath and optic nerve sheath, and digital motion x-ray (videofluoroscopy) and upright cone beam computed tomography scan of cervical spine. Results The analysis included 203/234 consecutive patients. Elevated optic nerve sheath diameter (total >12.2 mm) was documented in 98% (199/203). Supine cervical ultrasound revealed 99.5% (202/203) with internal jugular vein narrowing at C1: total internal jugular vein cross-sectional area <180 mm2. Mean internal jugular vein cross-sectional area at C1 was significantly higher with cervical orthotic Denneroll® (+35.76 mm, p < 0.05). Some 95.6% evidenced vagus nerve degeneration (total cross-sectional area <4.2 mm2) and 86.2% had C1-C2 instability (total >4.0 mm). Pearson correlation coefficient analysis showed a positive relationship between pupil diameter and intraocular pressure (r = 0.29, p < 0.01), while 20.7% had ocular hypertension. Discussion Elevated optic nerve sheath diameter, elevated intraocular pressure, ocular dysautonomia, and succeeding eye symptoms may be pathophysiological effects of internal jugular vein compression and vagus nerve degeneration with underlying ligamentous cervical instability etiology.
Source: Frontiers in Neurology
Authors: Ross A. Hauser, Morgan Griffiths, Ashley Watterson, Danielle Matias, Benjamin Rawlings
Institution: Claremont Graduate University
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4414401422