Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma
Year: 2025
Type: article
Abstract: Background: Mitochondria play an important role in tumors. Cellular energy supply, signaling, metabolism, autophagy, aging, and tumorigenesis are all associated with mitochondria. However, we lack a reliable prognostic model using mitochondrial-related genes in clear cell renal cell carcinoma (ccRCC). Methods: A systematic analysis of available TCGA databases and related studies was conducted using the R language and online analysis tools to evaluate the prognostic value of mitochondrial-related genes and the tumor microenvironment in ccRCC. Results: We constructed a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in ccRCC. The mitochondrial-related gene signature included MICALL2, FKBP10, and ACADSB. According to the risk score of the risk model, ccRCC patients were divided into high- or low-risk groups. The ccRCC high-risk group with a high-risk score is related to poor prognosis and poor efficacy from immune checkpoint inhibitors (ICIs). Conclusion: Our mitochondrial-related gene signature, as a risk model, could be a reliable ccRCC prognostic biomarker and could predict the response to immunotherapy. The risk score was correlated with the tumor microenvironment and immune cell infiltration.
Source: Frontiers in Genetics
Authors: Jiaxuan Qin, Lijian Zhang, Bowen Chen
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4414401468