Optical Camera Based Multiplexed Photonic Sensor System With Ultra Low Detection Limit For Biomedical Applications
Year: 2025
Type: article
Abstract: Photonic sensors based on Mach-Zehnder interferometric architectures with phase-coherent readout have demonstrated their potential for the integration into medical diagnostic devices. Their compact design, low cost and ability to detect multiple biomarkers make them potentially applicable for the point-of-care. Achieving both high throughput and optimal sensor performance requires a miniaturized interrogation system with multiplexed readout capability that facilitates alignment and at the same time offers a high signal-to-noise ratio. In this work the use of an optical camera based system suited for multiplexed integrated photonic sensor detection is investigated. Its system level model is derived to determine the signal-to-noise ratio and its associated limit of detection. This model allows achieving optimal sensing performance by tuning the photonic chip, the optical system and the camera detection parameters. In agreement with model expectations, experimental results show that this system allows reaching for bulk detection limits of ~ 10−7RIU (Refractive Index Units) for a system comprising three sensors, representing a state of the art achievement.
Authors: Laura Perez-Sanchez, Ana Sanchez-Ramirez, Jonas Leuermann, Iñigo Molina-Fernandez
Institution: Universidad de Málaga
Language: English
Topic: Advanced Fiber Optic Sensors
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4414404856
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