Work

Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

Year: 2025

Type: article

Abstract: Fungi in the gut microbiome, collectively known as the mycobiome, are a prevalent yet neglected component of the human holobiont. A major question in the study of gut microbial communities is whether fungi exhibit eco-evolutionary patterns that are consistent with partner fidelity and long-term associations. We compared gut fungal profiles across natural populations of humans and nonhuman primates and identified significant degrees of primate-mycobiome phylosymbiosis as well as human-enriched fungal taxa. Notably, subsets of fungi are cophylogenetic and exhibit cospeciation patterns in hominids. These findings cautiously originate a new view on the eco-evolutionary potential that can shape the composition of human and primate gut mycobiomes.

Source: PLoS Biology

DOI: 10.1371/journal.pbio.3003390

Authors: Emily P. Van Syoc, Andres Gomez, Emily R. Davenport, Seth R. Bordenstein

Institutions: Pennsylvania State University, University of Minnesota

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,500

Funders: Pennsylvania State University, National Institutes of Health, Institute for Computational and Data Sciences, Pennsylvania State University, National Institute of Diabetes and Digestive and Kidney Diseases