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Cobaloxime catalyzed carbene insertion into N–H bonds: a streamlined route to α-amino esters with mechanistic insights

Year: 2025

Type: article

Abstract: A cobaloxime-catalyzed N–H carbene insertion proceeds under mild conditions with low catalyst loading and broad amine scope. Mechanistic studies support a dominant cobalt–alkyl ylide pathway with minor radical involvement.

Source: Organic Chemistry Frontiers

DOI: 10.1039/d5qo01185j

Authors: Keyang Wu, Kirklin L. McWhorter, Ayzia Ford, Liming Tan, Lidia M. Waidmann, Jesus O. Vazquez Hernandez, Madeline M. Garcia, Katherine M. Davis, Gang Li

Institutions: Utah State University, Emory University

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, Utah State University, Emory University, Division of Chemistry, National Science Foundation Graduate Research Fellowship Program

Awards: G135240269, G196131894, Graduate Research Fellowship Program (GRFP), G5739541517, G6220723663, MRI: Acquisition of a 500 MHz NMR to Enhance Research and Training, Graduate Research Fellowship Program (GRFP)

OpenAlex ID: W4414408034

FWCI: 0.889

Cites: 106

Cited by: 3

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