Original Article Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort
Year: 2025
Type: article
Abstract: Background: Diabetes Mellitus (DM) is a leading chronic condition worldwide, affecting an estimated 537 million individuals between the ages of 20 and 79 years, equivalent to 10.5% of the world’s population. Micronutrients such as vitamin D and zinc have been suggested as potential modifiers of disease development; however, the literature often excludes older adults, resulting in limited data on their impact in this population. Methods: We conducted a secondary cross-sectional analysis of the NHANES 2017–2018 dataset. Participants older than50 years were included based on self-reported diabetes status. Logistic regression models (univariate and multivariate) were used to assess associations between micronutrient intake and diabetes, adjusting for age, BMI, gender, race, educational level, physical activity, thyroid comorbidities, smoking, and fat and sugar intake. Results: Of the 9,254 survey respondents, 1,172 met inclusion criteria. In univariate analysis, zinc intake (OR 0.98,95% CI 0.93–1.04,p=0.534) and vitamin D intake (OR 1.00, 95% CI 0.99–1.00,p=0.831) were not significantly associated with diabetes. In multivariate models, zinc (OR 1.02, 95% CI 0.91–1.14,p=0.666) and vitamin D (OR 0.99,95% CI 0.99–1.00,p=0.360) remained nonsignificant. Significant predictors included older age (OR 1.06 per year, 95%CI 1.04–1.08,p<0.001), female gender (OR 0.47 vs. males, 95% CI 0.35–0.64,p<0.001), race (Mexican-American OR1.79, 95% CI 1.06–3.02, p=0.029; Non-Hispanic Black OR 1.60, 95% CI 1.10–2.34, p=0.014), higher BMI (OR 1.10per kg/m2, 95% CI 1.08–1.13,p<0.001), and lower educational attainment (college graduate OR 0.53, 95% CI 0.33–0.84,p=0.007). The model demonstrated good discriminatory power (AUC = 0.73). Conclusion: No significant association was found between dietary zinc or vitamin D intake and diabetes in adults aged50 years and older. Demographic and anthropometric factors such as age, gender, race, BMI, and education were strongly linked to diabetes risk, with elevated risk observed among Mexican Americans and Non-Hispanic Blacks.
Authors: Daniel Bancovsky, Andressa Masson, Carla Chavarria, Caterina Paiva, Christiane de Freitas Paganoti, Daniel Abad, Daniella Audi, Dermeval Neto, Dominique Schakel, Elianet Castillo, Felipe Cordova, Fernanda Malta, Helio Grullon, Jose Fermin, Karen Bedirian, Kendya Jazmin Reyes Vasquez, Mobolaji Jaiyesimi, Nicol Ortega, Paula Sotelo, Santiago Pastrana-Brandes, Tomas Marques, Vanessa Lessa, Stefania Zapata, Tomas Mansur
Institutions: Harvard University, Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Gold Coast Hospital, Memorial Sloan Kettering Cancer Center, D’Or Institute for Research and Education, Instituto Nacional de Cardiologia, Clínica MEDS (Chile), Hospital del Trabajador, Boston University, Irmandade da Santa Casa de Misericórdia de São Paulo, AC Camargo Hospital
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414409113
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