Anti‐Inflammatory Efficacy of a Functional Shampoo Mixed With 0.063% Artemether for Seborrheic Dermatitis
Year: 2025
Type: article
Abstract: BACKGROUND: Seborrheic dermatitis (SD) is a chronic inflammatory skin disease. Artemisinin and its derivatives have been applied in the treatment of various skin diseases, but they have not yet been used in the treatment of SD. AIMS: To evaluate the therapeutic effect and anti-inflammatory effect of 0.063% artemether shampoo on SD through a guinea pig model. METHOD: Fifty SD-induced guinea pigs were randomized into control, ketoconazole (2%), matrix, and artemether (0.063%) groups (n = 10/group). Treatments were applied twice weekly for 2 weeks. Erythema and scaling were scored pre-/posttreatment. Lesional IL-1β, IL-8, IL-17, NF-κB, and histamine H1 levels were quantified via immunohistochemistry. RESULTS: Artemether group demonstrated lower scores versus control and matrix group (both p < 0.05), comparable to ketoconazole group (p > 0.05). Artemether group reduced IL-1β, IL-8, NF-κB, and histamine H1 vs. control group(p < 0.05), with IL-8 suppression exceeding ketoconazole and matrix group (p < 0.05; p < 0.001). No intergroup differences in IL-17 were observed (p > 0.05). CONCLUSION: The 0.063% artemether shampoo has comparable clinical efficacy to the 2% ketoconazole shampoo in the treatment of SD, and may exhibit stronger anti-inflammatory effects.
Source: Journal of Cosmetic Dermatology
DOI: 10.1111/jocd.70461
Authors: Qin Pei, Yue Yu, Mei‐Lin Huang, Mao‐Lin Zhou, Jian‐Biao Fei, Hai‐Hong Qin
Institution: Shanghai University of Medicine and Health Sciences
Language: English
Topic: Nail Diseases and Treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,020
OpenAlex ID: W4414410332