Work

mGem: Extracellular vesicles in Leishmania —secret messengers driving infection and disease

Year: 2025

Type: article

Abstract: ABSTRACT Leishmaniasis is a disease caused by Leishmania parasites, transmitted by insects, that occurs worldwide. The parasite and parasite-infected cells release extracellular vesicles (EVs), which are involved in numerous biological processes. EVs secreted by Leishmania modulate the host cell and, in turn, the immune response. In this review, we focused on two particular EV-related topics: (i) EVs as carriers of Leishmania virulence factors and implications in parasite biology, and (ii) the effects of Leishmania -derived EVs on the host’s immune response.

Source: mBio

DOI: 10.1128/mbio.03239-24

Authors: Patricia Xander, Camila I. de Oliveira

Institutions: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais, Fundação Oswaldo Cruz

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900