Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
Year: 2023
Type: review
Abstract: BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB). OBJECTIVES: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations. METHODS: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort. RESULTS: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration. CONCLUSIONS: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.
Authors: Nagendra K. Monangi, Huan Xu, Yue-Mei Fan, Rasheeda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan T. Price, Lovejeet Kaur, Jose Villar, Rose McGready, Fernando C. Barros, Cesar G. Victora, Shama Munim, Aris T. Papageorgh, Roseline Ochieng, Rachel Craik, Hellen C. Barososio, James A. Berkley, Maria Carvalho, Leila Cheikh Ismail, Ann Lambert, Shane A. Norris, Chrystelle OO. Tshivuila-Matela, Francois Nosten, Ricardo Uauy, Zulfiqar A. Bhutta, Stephen Kennedy, Abdullah Al Mahmud, Le Quang Thanh, Angharad Care, Julio A. Landero, Gerald F. Combs, Elizabeth Belling, Joanne Chappell, Jing Chen, Fansheng Kong, Craig Lacher, Salahuddin Ahmed, Nabidul Haque Chowdhury, Sayedur Rahman, Furqan Kabir, Imran Nisar, Aneeta Hotwani, Usma Mehmood, Ambreen Nizar, Javairia Khalid, Usha Dhingra, Arup Dutta, Said Mohamed Ali, Fahad Aftab, Mohammed Hamad Juma, Monjur Rahman, Tahmeed Ahmed, M Munirul Islam, Bellington Vwalika, Patrick Musonda, Ulla Ashorn, Kenneth Maleta, Mikko Hallman, Laura Goodfellow, Juhi K. Gupta, Ana Alfirevic, Susan K. Murphy, Larry Rand, Kelli K. Ryckman, Jeffrey C. Murray, Rajiv Bahl, James A. Litch, Courtney Baruch-Gravett, Shailaja Sopory, Uma Chandra Mouli Natchu, Pavitra V. Kumar, Neha Kumari, Ramachandran Thiruvengadam, Atul Kumar Singh, Pankaj Kumar, Zarko Alfirevic, Abdullah H. Baqui, Shinjini Bhatnagar, Jane E. Hirst, Cathrine Hoyo, Fyezah Jehan, Laura Jelliffe-Pawlowski, Anisur Rahman, Daniel E. Roth, Sunil Sazawal, Jeffrey S.A. Stringer, Per Ashorn, Ge Zhang, Louis J. Muglia
Institutions: Cincinnati Children's Hospital Medical Center, March of Dimes Prematurity Research Center Ohio Collaborative, University of Cincinnati, Tampere University, University of Tampere, Johns Hopkins University, Aga Khan University, Public Health Laboratory Ivo de Carneri, International Centre for Diarrhoeal Disease Research, University of North Carolina at Chapel Hill, Translational Health Science and Technology Institute, University of Oxford, Mahidol University, Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Universidade Católica de Pelotas, Universidade Federal de Pelotas, Aga Khan University Nairobi, Liverpool School of Tropical Medicine, Kenya Medical Research Institute, KEMRI-Wellcome Trust Research Programme, University of Liverpool, Tufts University, Jean Mayer Human Nutrition Research Center on Aging, Agricultural Research Service, United States Department of Agriculture, Grand Forks Human Nutrition Research Center, University of Zambia, University of Malawi, University of Oulu, Duke University, Duke Medical Center, University of California, San Francisco, University of California San Francisco Medical Center, University of Iowa, University of Iowa Health Care, World Health Organization, Global Alliance to Prevent Prematurity and Stillbirth, St. John's Research Institute, Inter-University Accelerator Centre, North Carolina State University, University of Toronto, Hospital for Sick Children, Tampere University Hospital, Burroughs Wellcome Fund
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
Funders: U.S. Environmental Protection Agency, United States Agency for International Development, Bill and Melinda Gates Foundation, March of Dimes Foundation, World Health Organization, FHI 360, South African Medical Research Council, Department of Biotechnology, Ministry of Science and Technology, India, Ministry of Earth Sciences, University of California, Davis, University of California, San Francisco, March of Dimes Prematurity Research Center Ohio Collaborative, Canadian Institutes of Health Research, Inter-University Accelerator Centre, Biotechnology Industry Research Assistance Council, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, Duke Cancer Institute
Awards: G1992967553, G2414503091, G260437639, G4430510796, Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort, FANTA III, G5286067362, G5287754643, G5482967079, Obesity and deregulation of imprinted genes in early life, G6413334086, Global Alliance to Prevent Prematurity and Stillbirth - to generate scientific discoveries that will be made readily available to the global community to facilitate more rapid development of equitable an..., G7432449934, G7596011521, Hospital for Sick Children - to contribute new knowledge regarding causes of fetal and early infant under nutrition in resource-poor settings and to identify novel targets of i..., G8113048153, Duke University Program in Environmental Health
OpenAlex ID: W4387953020