Work

No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH

Year: 2025

Type: article

Abstract: Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers. Both conventional and FLASH radiotherapy yielded similar survival benefits; however, conventional radiotherapy resulted in greater normal tissue DNA and RNA damage.

Source: Clinical and Translational Radiation Oncology

DOI: 10.1016/j.ctro.2025.101050

Authors: Taylor L. Schanel, Manoj Kumar, Lauren C. Nassour-Caswell, Sreelakshmi Cherakara, Rhea Pandit, Andee M. Beierle, Joshua C. Anderson, Patrica H. Hicks, Rex Cardan, Anita B. Hjelmeland, Christopher D. Willey

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Radiation Therapy and Dosimetry

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,430

Funders: Varian Medical Systems, Universitat Autònoma de Barcelona, National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke

Awards: Training Program in Brain Tumor Biology, G2457495176, Biological Comparisons Among Three Derivative Models of Glioma Patient Cancers Under Microenvironmental Stress, G6297189420

OpenAlex ID: W4414416877

FWCI: 1.174

Cites: 29

Cited by: 2

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