Work

Effect of Serum Ferritin Level on the Response to Standard Chemotherapy in Acute Myeloid Leukemia Patients

Year: 2025

Type: article

Abstract: Background: A high ferritin level in acute myeloid leukemia (AML) patients acts as a growth factor for leukemic cells, and its antioxidant effect may reduce the effectiveness of cytotoxic chemotherapy drugs, including anthracyclines. Methods: All adult patients with AML from 2013 to 2023, who had received 7+3 chemotherapy protocol at Namazi and Amir hospitals in Shiraz provided that Ferritin and C-reactive protein (CRP) level were checked before chemotherapy were included. We evaluated complete remission rate, overall survival (OS) and event-free survival (EFS) in 67 new cases. Results: The EFS was significantly longer in patients with serum ferritin levels below 1000 ng/mL compared to those with serum ferritin levels of 1000 ng/mL or higher [estimated mean and 95% CI: 25.65 (19.29 - 32) vs 11.6 (8.19 - 15.13) months, P = 0.018]. Conclusions: Ferritin levels at diagnosis are indicative of patient survival. The AML patients with serum ferritin levels greater than 1000 experienced shorter EFS compared to those with ferritin levels below 1000.

Source: Shiraz E-Medical Journal

DOI: 10.5812/semj-161086

Authors: Nasrin Namdari, Ali Ghane-Shahmirzadi, Sezaneh Haghpanah, Maral Mokhtari

Institutions: Shiraz University of Medical Sciences, Shiraz University

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414418611