Work

Retinal hypoxia reversal with PLGA-oxygen nanobubbles

Year: 2025

Type: article

Abstract: in Muller and R28 retinal cell lines demonstrated excellent biocompatibility and potential to mitigate hypoxia. In addition, the PLGA-ONBs treatment on hypoxic cells demonstrated restoration of mRNA expression of three key hypoxic genes (HIF-1α, PAI-1, and VEGF-A) to normoxic states, indicating hypoxia reversal potential. Biosafety of the PLGA-ONBs was demonstrated in a rabbit model, demonstrating promise in clinical translation. The PLGA-ONBs developed exhibited excellent oxygen loading and retention, potential in hypoxia mitigation, and a safety profile that could be a promising route to treating ischemic diseases of the eye.

Source: Biomaterials Science

DOI: 10.1039/d5bm01154j

Authors: Anika Bushra, Wen Ren, Daniel Um, Xiaoxue Han, Michael Tsipursky, Joseph Irudayaraj

Institutions: Carle Foundation Hospital, University of Illinois Urbana-Champaign, Cancer Center at Illinois, Carl R. Woese Institute for Genomic Biology

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Science Foundation