Work

NRG‐1 Promotes Axon Regeneration of Dorsal Root Ganglion Neurons in Diabetic Rats via ITGB1/FAK/AKT Pathway

Year: 2025

Type: article

Abstract: Objectives: The purpose of this study was to investigate the role of the ITGB1/FAK/AKT pathway in NRG‐1 in mediating the axonal growth of dorsal root ganglion neurons in Type I diabetic rats and to explore the mechanism of neuronal axonal regeneration. Result: The effects of NRG‐1 on neurite outgrowth in diabetic rats were determined by protein quantification and axon length analysis in which axons were identified with tubulin‐ β III‐specific staining. Western blot showed that the signaling activity of the ITGB1/FAK/AKT pathway was decreased in diabetic rats compared with normal rats, and exogenous NRG‐1 significantly promoted axonal growth and activated the pathway. After the addition of ITGB1‐specific siRNA, the axonal growth–promoting effect of NRG‐1 was partially reversed. Conclusion: NRG‐1 promotes axonal outgrowth in diabetic DRGs via upregulating the ITGB1/FAK/AKT pathway, providing a potential target for diabetic neuropathy.

Source: International Journal of Genomics

DOI: 10.1155/ijog/5520810

Authors: Peng Zhan, Hewei Xiong, Hongmei Zheng

Institutions: Hubei Cancer Hospital, Huazhong University of Science and Technology, Wuhan Union Hospital

Language: English

Topic: Nerve injury and regeneration

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,380