Single-step purification and formulation of antibody-drug conjugates using a miniaturized tangential flow filtration system
Year: 2025
Type: article
Abstract: for SEC+DEF, ensuring validation of the safe application of purified ADCs in living systems. However, the µPulse performed purification and formulation of ADCs simultaneously as compared to SEC+DEF, which required multiple manual interventions. Our results indicate that the µPulse is a gentle, single-step, and walk-away approach for the purification of ADCs.
Source: SLAS TECHNOLOGY
Authors: Muhammad Sajed, Zahoor Khan, Muhammad Usman Ashraf, Hafsa Iftikhar, Talha Bin Rahat, Samia Falak, Salman Fozail, Quiterie Gue, Raul Pardo, Lance Ramsey, Muhammad Saqib Shahzad
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,070
OpenAlex ID: W4414422305