Work

Anti-TIF-1γ-positive dermatomyositis associated with colorectal adenocarcinoma: a case report

Year: 2025

Type: article

Abstract: Dermatomyositis (DM) is a rare autoimmune disease characterized by inflammatory involvement of the skin and muscles, often associated with malignancy, particularly in the presence of anti-transcription intermediary factor 1 gamma (TIF-1γ) antibodies. This case report describes a 57-year-old Senegalese man with anti-TIF-1γ-positive DM and colorectal adenocarcinoma with liver metastases, presenting with severe dermatological symptoms such as ulcerations, the "red on white" sign, and scalp pustulosis, as well as systemic features including dysphagia and muscle weakness. Diagnosis was confirmed through clinical evaluation, serological testing, and histopathology. Treatment with corticosteroids, intravenous immunoglobulin (IVIG), and surgical tumor resection led to significant improvement. This case underscores the importance of recognizing DM's dermatological signs, conducting thorough malignancy screening, and implementing a multidisciplinary approach for effective management and improved outcomes, given the rarity of the association with colorectal cancer.

Source: Dermatology Reports

DOI: 10.4081/dr.2025.10489

Authors: Sofia Spagnolini, Arlind Kalaja, Stefano Macchi, Ignazio Stanganelli, Maria Beatrice De Felici Del Giudice

Institutions: University of Parma, Ospedale Sant'Anna, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $539