Work

All roads lead to TDP43: Convergent mechanisms of TDP43 autoregulation

Year: 2025

Type: article

Abstract: TDP43 is an essential RNA-binding protein with fundamental ties to neurodegenerative disorders. In this issue, Hasegawa-Ogawa and colleagues (https://doi.org/10.1083/jcb.202406097) describe a new mechanism for regulating TDP43 function, involving alternatively spliced variants that inhibit TDP43 via dominant-negative activity.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202508101

Authors: Morgan R. Miller, Sami J. Barmada

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, National Institutes of Health, National Institute of Neurological Disorders and Stroke