Perspectives of the European Association of Nuclear Medicine (EANM) on early perfusion imaging in the context of amyloid PET imaging protocols
Year: 2025
Type: article
Abstract: Early perfusion amyloid-PET imaging is emerging as a valuable tool to potentially capture patients’ neurodegeneration patterns, allowing same-day, same-tracer categorization of both amyloidosis (A) and neurodegeneration (N) biomarkers. Early perfusion amyloid-PET might provide an added value for differential diagnosis and, in keeping with the capability of FDG-PET to indirectly track co-pathology in AD patients, it may complement the information provided by amyloid PET thus supporting a more accurate weighting of the different underlying pathological processes. Early perfusion imaging is, at the moment, still a research tool, as high-level evidence regarding a non-inferiority with respect to FDG-PET (especially in MCI patients) is still not available due to the lack of dedicated clinical trials. The present paper states the position of EANM on early perfusion imaging in the framework of dual-point amyloid-PET studies. The mounting evidence for its use, as well as unmet needs and potential cost-effectiveness, are summarized and discussed with the aim of paving the path for a proper recognition of its added value in the AT(N) system and in the clinical setting to further support differential diagnosis.
Source: The EANM Journal
Institutions: Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, Ghent University Hospital, Inserm, Centre Hospitalier Régional et Universitaire de Nancy, Imagerie Adaptative Diagnostique et Interventionnelle, Université de Lorraine, University Medical Center Utrecht, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases, Instituto de Investigación Sanitaria de Santiago, German Center for Neurodegenerative Diseases, LMU Klinikum, Munich Cluster for Systems Neurology, Ludwig-Maximilians-Universität München, Centre National de la Recherche Scientifique, Aix-Marseille Université, Institut Fresnel, Centrale Méditerranée, Hôpital de la Timone, Centre Européen de Recherche en Imagerie Médicale, University of Geneva, University Hospital of Geneva, University of Padua, Azienda Ospedale - Università Padova, TUM Klinikum, Technical University of Munich, Amsterdam Neuroscience, Amsterdam UMC Location Vrije Universiteit Amsterdam, University College London, Medical University of Vienna, Städtisches Klinikum Dessau, University Hospital Leipzig, Leipzig University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414437455