KAZN methylation as a potential diagnostic and prognostic marker in non-small cell lung cancer
Year: 2025
Type: article
Abstract: experiments validated that KAZN expression is significantly lower in NSCLC tumor tissues and cell lines compared to normal controls. Demethylation treatment significantly elevated KAZN expression in lung adenocarcinoma cell lines. KAZN expression significantly affects the apoptosis and proliferation in NSCLC cell lines by potentially targeting USP2. Overall, aberrant methylation of KAZN plays an important role in NSCLC pathogenesis and KAZN methylation may serves as a useful biomarker for molecular characterization, diagnosis, and prognosis.
Source: iScience
Authors: Songling Zhu, Yuting He, Wei Wang, Yanlei Jiao, Ziqiong Xu, Shaohui You, Chong Yu, Jiayi Ao, Mengran Long, Jihong Ren, Hongli Zhang, Shu-Lin Liu, Hongxia Bao, Shuang Wang
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
OpenAlex ID: W4414440547