Work

Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation

Year: 2025

Type: article

Study design: Observational Study

Abstract: BACKGROUND: There is a paucity of data on neurodevelopmental outcomes in preterm infants who undergo transcatheter patent ductus arteriosus (PDA) closure (TCPC). OBJECTIVE: To evaluate neurodevelopmental impairment (NDI) or death at 2 years among preterm infants treated with TCPC compared to surgical ligation. METHODS: Retrospective cohort study of infants born at <27 weeks' gestation at NICHD NRN sites. Comparisons were made between infants who underwent TCPC and PDA ligation. RESULTS: TCPC and surgical ligation were performed on 99 and 279 infants, respectively. Death or severe NDI occurred in 49% of infants with TCPC and 40% with surgical ligation. There was no difference in odds of death or severe NDI between the two groups [aOR 1.12 95% CI: 0.55-2.26)]. CONCLUSION: TCPC had similar odds of death or severe NDI compared to surgical ligation. These findings need to be evaluated in large prospective studies as the management practice around the TCPC evolves. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov ID: Generic Database: NCT00063063.

Source: Journal of Perinatology

DOI: 10.1038/s41372-025-02417-8

Authors: D. C. Kaluarachchi, V. Y. Chock, B. T. Do, M. A. Rysavy, M. N. Sankar, M. M. Laughon, C. H. Backes, T. T. Colaizy, E. F. Bell, P. J. McNamara, S. R. Hintz, G. Natarajan

Institutions: University of Wisconsin–Madison, Stanford University, RTI International, The University of Texas Health Science Center at Houston, University of North Carolina at Chapel Hill, Nationwide Children's Hospital, The Ohio State University, University of Iowa, Wayne State University

Language: English

Topic: Cardiovascular Conditions and Treatments

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790

Funders: National Institutes of Health, National Institute of Child Health and Human Development, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1029946750, G1035361083, G1037055288, Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1, G1186807586, University of New Mexico Clinical and Translational Science Center, G1352838917, G1421780561, G1442547618, G1533337087, G158642924, G1658985302, G1793787542, G1801374632, G1972173448, G1981379474, G2001941347, Rochester-Buffalo Neonatal Research Group, NICHD Cooperative Multicenter Neonatal Research Network, G2366643028, G245809433, Duke CTSA (Composite), G2680676337, G2715018881, NICHD Neonatal Research Network (NRN), G3042997015, G3189020257, G3360186718, G3399879591, G3547804312, G3566384843, G3611579263, G3654557411, One Center, Two States, G3945656891, G4408328601, G4423566278, G4505422504, G4621247372, Cooperative Multicenter Network of Neonatal Intensive Care Units, G4682061961, G4881643641, G5028210595, G5033150653, G5173431040, Multicenter Network of Neonatal Intensive Care Units, G5422669700, G5425378458, Neonatal Research Network Data Coordinating Center (DCC), Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, G6111235625, G6149667125, G6198151190, G6229692350, G6239958052, G6315228394, G6481205343, G6521818577, G6726963199, G6824599950, G6827789451, G6827829896, The University of Rochester's Clinical and Translational Science Institute, G7054807377, G7417610757, G7448329892, G7503077049, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, G7614407291, G7792775406, Indiana Clinical and Translational Science Institute (UL1), University of Iowa Clinical and Translational Science Program, NICHD Neonatal Research Network, G807757620, Multicenter Network of Neonatal Intensive Care Units-University of Texas at Houston (UT Houston) Clinical Center, G8429169078, G8485215240, G8621868819, Cincinnati Center for Clinical and Translational Sciences and Training, University of Utah Center for Clinical and Translational Science-UL1, Data Ctr for the Cooperative Neonatal Research Network, G8984540923, G9000244971, G9000353486, NICHD Neonatal Research Network Clinical Center UAB, NICHD Cooperative Multicenter Neonatal Research Network - Utah Center, NICHD Neonatal Research Network -- Cincinnati Clinical Center, NICHD Neonatal Research Network - Stanford University, NICHD Neonatal Research Network Clinical Center - Case Western Reserve University, NICHD Neonatal Research Network, HEAL Initiative: Antenatal Opioid Exposure Longitudinal Study Consortium, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal ResearchNetwork, Clinical Center for NICHD/Neonatal Research Network, NICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORK, NICHD Cooperative Multicenter Neonatal Research Network, North Carolina Clinical Center, NICHD Neonatal Research Network (NRN): Clinical Centers (UG1 Clinical Trial Optional

OpenAlex ID: W4414440824

FWCI: 2.122

Cites: 24

Cited by: 4

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