Work

Direct Cyclization/Chlorination Strategy of Hydrazines for Synthesis of 4-Chloropyrazoles by TCCA

Year: 2025

Type: article

Abstract: A new method for synthesis of various 4-chloropyrazoles through the direct cyclization/chlorination of hydrazines by using 1,3,5-trichloroisocyanuric acid (TCCA) as both oxidant and chlorinating agent under mild conditions has been proposed. Based on the detailed optimization of the reaction conditions, the substrate generality has been investigated, and the yields of the desired products are up to 92%.

Source: Molecules

DOI: 10.3390/molecules30193841

Authors: Qingfu Deng, Chenglong Ma, Liangzhen Hu, Yan Xiong

Institutions: Chongqing Chemical Industry Vocational College, Chongqing University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: National Natural Science Foundation of China, Chongqing Science and Technology Commission, Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission, Research and Innovation Foundation