47 Year Old Female with a Recurrent Abdominal Perivascular Epithelioid Cell Tumor: Case Report and Literature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms characterized by histologically and immunohistochemically distinctive epithelioid or spindle cells. These tumors express both smooth muscle markers and melanocytic markers. They can arise in various anatomical locations throughout the body, including the gastrointestinal tract, genitourinary system, retroperitoneum, and soft tissues. The exact cell of origin for these tumors remains unidentified. Clinical outcomes vary widely, spanning benign to malignant behavior, with the potential for local recurrence and metastasis. The management of PEComas typically involves surgical resection, though use of adjuvant chemotherapy and immunotherapy has been reported. The high recurrence rate of PEComas highlights the necessity for long-term surveillance and a multidisciplinary approach to treatment. We present the case of a 47-year-old female with a previous abdominal PEComa, who presented to our clinic with an enlarged recurrent abdominal tumor. Confirmation of recurrence was obtained through ultrasound and PET-CT imaging. Additionally, post-operative pathology findings supported the diagnosis.
Source: Sakarya Medical Journal
DOI: 10.31832/smj.1535871
Authors: Ali Yosef, Ugur Dulger, Metin Ercan, Bilge Elçin
Institutions: Sakarya University, Sakarya Eğitim ve Araştırma Hastanesi
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414441499