The state of vaginal microbiocenosis of adolescent girls with urinary tract and gastrointestinal diseases
Year: 2025
Type: article
Study design: Observational Study
Abstract: Justification. Changes in the microbiocenosis of the vagina of adolescent girls with diseases of the urinary tract and gastrointestinal tract may be a marker of future diseases of the reproductive system. Currently, more than 20 types of vaginal lactobacilli have been identified, the relationship of which among themselves and with other microorganisms can be a predictor of vulvovaginitis. These issues are relevant and poorly understood among adolescent girls. The aim of this study. To determine the features of vaginal microbiocenosis and to establish factors preventing the vulvovaginitis in adolescent girls of the hospital sample. Materials and methods. The analysis of the vaginal microbiocenosis of 60 adolescent girls in a hospital sample with urinary tract and gastrointestinal diseases was performed using microscopic, bacteriological, and molecular genetic research methods (species typing of lactobacilli). Results. In 53.4 % and 46.6 % of cases of urinary tract and gastrointestinal diseases in adolescent girls had vulvovaginitis, regardless of the reason for hospitalization (p = 0.82). Moderate vulvovaginitis (5–6 points on the ISSVD score) is associated with microorganisms such as Escherichia coli (103–106 CFU/ml) and Staphylococcus aureus (103–104 CFU/ml) and the absence of lactobacilli (OR = 10.4 95% CI [0.90; 120.2], p = 0.03; OR = 7.5, 95% CI [0.61; 91.8], p = 0.18). In adolescent girls without vulvovaginitis, vaginal microbiocenosis is characterized by the dominance of lactobacilli (88.3 %); L. crispatus (46.0 %) and L. gasseri (30.7 %). In adolescent girls with urinary tract diseases, the number of lactobacilli greater than 105 CFU/ml reduces the risk of developing vulvovaginitis by 7.7 times, in adolescent girls with gastrointestinal diseases – by 8.3 times (OR = 0.13, 95% CI [0.03; 0.65] and OR = 0.12, 95% CI [0.02; 0.63]). Conclusion. Vulvovaginitis is often associated with diseases of the urinary tract and gastrointestinal tract in adolescent girls. The number of lactobacilli exceeding 105 CFU/ml and the dominance of L. crispatus are a significant protective factor against the development of vulvovaginitis (p = 0.002).
Authors: M. Yu. Akhmetova, V. V. Florensov, O. Ya. Leshchenko, O. E. Baryaeva, L. I. Kolesnikova
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414452340