Treatment Response to Mavacamten in Patients With Obstructive Hypertrophic Cardiomyopathy: 96-Week Results From the EXPLORER Cohort of the MAVA–Long-Term Extension Cardiac Magnetic Resonance Imaging Substudy
Year: 2025
Type: article
Abstract: All participants provided written informed consent?a In EXPLORER-HCM. patients received mavacamten or placebo for 30 weeks. After trial completion and a variable washout period, patients could enroll in MAVA- LTE. with initiation of mavacamten 5 mg/day and echocardiography-guided titration. CMR assessments were conducted as previously detailed? with analyses at baseline and week 30 of EXPLORER-HCM and weeks |24 and 96 of MAVA-LTE (data extraction on March 9, (2023). Exploratory end points included left ventricular (LV) mass index, LV maximum wall thickness, volumes land function (left atrial volume maximum index, LV end- diastolic volume index, LV end-sys tolic volume index, and myocardial contractile fraction), focal and diffuse mocar- dial fibrosis (6-SD late gadolinium enhancement [LGE] and average extracellular volume fraction), and LV ejec- tion fraction (LVEF).
Source: Circulation
Authors: Sara Saberi, Christopher M. Kramer, Artur Oręziak, Ahmad Masri, Roberto Barriales-Villa, Theodore P. Abraham, Neal K. Lakdawala, Andrew Wang, Lubna Choudhury, Florian Rader, Ofer Havakuk, John C. Stendahl, Nuno Cardim, Tim Seidler, Mark Sherrid, Sheila M. Hegde, Raymond Y. Kwong, Michael Jerosch-Herold, Ganesh Balaratnam, Gregory Kurio, Shawna Fox, Iacopo Olivotto, Anjali Owens
Institutions: University of Michigan, University of Virginia Health System, University of Virginia, Institute of Cardiology, Oregon Health & Science University, Complexo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña, University of California, San Francisco, Brigham and Women's Hospital, Duke University, Northwestern University, Cedars-Sinai Medical Center, Tel Aviv University, Tel Aviv Sourasky Medical Center, Yale University, Hospital da Luz, Universitätsmedizin Göttingen, Kerckhoff Klinik, University of Göttingen, NYU Langone Health, Bristol-Myers Squibb (United States), Meyer Children's Hospital, University of Pennsylvania
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4414452818